Robust Reagents. Rapid Results.

Traditional methods of microbial testing rely heavily on lengthy incubation periods to achieve visible growth, for colonies to grow large enough for confident enumeration in microbial limits, or for unambiguous turbidity in sterility testing. Celsis® ATP bioluminescence-based rapid detection can reduce these incubation periods by 50%.

As an automated rapid microbial test for aseptic and sterile manufacturing processes, Celsis® ATP-bioluminescence reagents will quickly screen for the absence or presence of bacteria, yeasts, and molds, allowing the release of final products through instrument-based analysis, following a shortened incubation time.

Celsis® ATP-bioluminescence Reaction

The fundamentals of Celsis® reagents are simple, yet powerful. Celsis® rapid microbial detection reagent technology is based upon a naturally occurring, ATP-bioluminescence reaction, which also provides the characteristic glow of fireflies.

The ATP-bioluminescence Assay is commonly known as the luciferin-luciferase reaction or luciferase assay, this reaction occurs when the luciferase enzyme converts luciferin into oxyluciferin to produce light in the presence of adenosine triphosphate (ATP). Only when ATP is present will this reaction occur. Since ATP is present in all living cells, including prokaryotes, it can be used as a microbial testing marker for contamination if a sample should not, under normal conditions, contain ATP.

Celsis AMPiScreen® reagents

Celsis AMPiScreen® reagents rapidly detect the presence of ultra-low levels of microbiological contamination up to 50% faster than other on-market ATP bioluminescence methods, with compatible sample types. The amplified-ATP assay, used in Celsis AMPiScreen®, is not constrained by the limited amount of metabolic ATP in the organism. Instead, it produces additional ATP by using an enzyme-catalyzed reaction and an additional instrument-controlled amplification period to optimize the detection of microorganisms.

Celsis Ampiscreen® AP reagents reduce high background in test samples, making it easier and more accurate than ever to detect microbial contamination in personal care, cosmetic, home care and over the counter products. This is especially important for brands owning products in the all-natural, organic or botanical space.

Features of Celsis® Rapid Microbial Detection Reagent:

  • Celsis AMPiScreen® Reagent is compatible with Celsis Accel® and Celsis Advance II™ luminometers.
  • Optimized reagent kit size and volume to minimize waste and improve reagent consumption efficiency.
  • Leverages the same in-house expertise that produces our industry-leading FDA-licensed Endosafe® reagents, trusted across the pharmaceutical industry.
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